Destroy All Humans!

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Destroy All Humans!

NTSC-U Boxart
Game general and emulation properties:
CERO rating: C
ESRB rating: T (Language, Sexual Themes, Violence)
PEGI rating: 12+
Widescreen supported natively
Progressive scan supported
Languages supported:
English: SLES-53196 & SLUS-20945 & SLUS-20945GH & SLUS-29150
Japanese: SLPM-66430 & SLPM-55141
German: SLES-53197
French: SLES-53196
Spanish: SLES-53196
Italian: SLES-53196
Region NTSC-U:
Serial numbers: SLUS-20945
SLUS-20945GH (Greatest Hits)
SLUS-29150 (Demo)
Release date: June 21, 2005
2006 (Greatest Hits)
Windows Status: Playable
Linux Status: ?
Mac Status: ?
Region PAL:
Serial numbers: SLES-53196
Release date: June 24, 2005
CRCs: E3E8E893
Windows Status: Playable
Linux Status: Playable
Mac Status: ?
Region NTSC-J/C/K:
Serial numbers: SLPM-66430
SLPM-55141 (THQ Collection)
Release date: February 22, 2007
January 22, 2009 (THQ Collection)
Windows Status: ?
Linux Status: ?
Mac Status: ?

Developer(s): Pandemic Studios
Publisher(s): THQ (US, EU, JP), Sega (JP)
Genre: Action, Adventure
Wikipedia: Link
Game review links: Metacritic74/100
Game description: This is your chance to experience the other side of an alien invasion. In Destroy All Humans!, you play as an alien who must use a UFO, advanced weaponry, and special abilities to take over all of humanity. You'll terrorize the people of Earth with a variety of alien weaponry--the Ion Detonator, the Zap-O-Matic, and the Sonic Boom, or even the Quantum Deconstructor--on land or in the air.
The game is set in the late 1950s in the U.S. and parodies the lifestyles, pop culture, and politics of this time period. The player controls Cryptosporidium 137 (a reference to the protozoan parasite Cryptosporidium), a member of the Furon race of alien life, who has come to Earth to harvest DNA from humans to continue the cloning process of his species. Destroy All Humans! is an open world game.

Test configurations on Windows:

Environment Configurations Comments Tester
Region OS CPU/GPU Revision Graphics Sound/Pad
PAL (?) ?
  • Intel Core i5-2500K @ stock settings
  • MSI GeForce GTX 470 Hawk @ 758 MHz core
r4600 GSdx r4643 0.1.16
  • SPU2-X r4600m 1.4.0
  • LilyPad r4510 0.10.0
FPS: 55-60, Minor full screen graphical glitch, still playable. Scaling kills this game, uses ~1100mb vram at 2x Scaling Lagahan
  • Intel Core i5-2500K @ 3400 MHz
  • NVIDIA GeForce GTX 460 SE 768 MB
v1.1.0 r5423 GSdx r5412
  • SPU2-X v2.0.0 r5421
  • LilyPad v0.11.0 r5403
HACKS: Skipdraw 5. Although it fixes the full screen shadow problem, it also introduces a new glitch. Naming the radar outline disappears. Moreover the mothership menu has disappearing menu items. eg. Pox's lab is gone with this hack enabled. No "Press Start" sign during start screen., Runs fine in hardware mode at 3x upscale. Skipdraw 5 needed in this mode. Check known issues. Software mode has no graphical issues. The game is fully playable. Be aware that sw mode is highly demanding. With above PC specs it uses around 70% CPU power! Can get slowdowns in intense fightings. Yuri
NTSC-U Windows
  • Intel Core i7 @ 3.4 GHz
  • Nvidia GeForce GTX 285 768 MB
1.1.0 r5480 GSdx 5442 SSE41
  • SPU2-X 2.0.0
  • LilyPad 0.11.0
Runs above full speed. Picture has garbage in it in GSdx hardware mode. Looks fine in software mode.
NTSC-U Windows 8.1
  • AMD FX-8350 @ 4.0GHz
  • NVIDIA Nvidia GeForce GTX 970 3.5GB
v1.2.1 r5873 GSdx r5875
  • SPU2-X v2.0.0 r5830
  • LilyPad v0.11.0 r5822
Software FPS(During heavy combat): 50-60

Hardware FPS(During heavy combat): 57-60 Alterations: Speedhacks enabled with EE Cyclerate on 3, 4x native resolution and skipdraw set to 5 The game looks good in software mode, but in hardware mode, some textures are garbled, but its not horribly distracting.

NTSC-U Windows 10 Pro
  • Intel I7 6700k @ 4.00Ghz
  • NVIDIA Nvidia GeForce GTX 980 Ti 6048MB
v1.5.0-dev-2414 GSdx MSVC 19.0 AVX2/AVX2, DirectX 11 (Software)
  • SPU2-X v2.0.0
  • LilyPad v0.12.1
Fullspeed with no noticeable slowdown. Used the ingame 16:9, and progressive scan option.

Samll semi-transparent blocky textures appear on the earth during the Earth/Mothership loading screen. No Object fell through the game world during testing, Even during the most intense missions.

NTSC-U Windows 10
  • AMD FX-6300 @ 4.10 GHz
  • MSI Nvidia GeForce GTX 1060 6GB
v1.5.0 r3302 GSdx 1.1.0 SSE4,OpenGL (Hardware)
  • SPU2-X 2.0.0
  • LilyPad 0.12.1
Use skipdraw range of 2:5 instead of 5:5 to get rid of blocky shadow glitch without making the game blurry, I have found this to be the best way to play the game without going into Software Mode. Trak55

Test configurations on Linux:

Environment Configurations Comments Tester
Region OS CPU/GPU Revision Graphics Sound/Pad
PAL Solus, kernel 5.0.16
  • Intel Core i5-4570 CPU @ 3.20GHz
  • NVIDIA GeForce GTX 650 2 GB
1.5.0 (075a9f3) GSdx 1.1.0 AVX2
  • SPU2-X 2.0.0
  • OnePAD 0 1.3.0
Works full speed on software mode. No issues found. Hardware mode has some minor effect issues. Ratchet66


  • Original names: デストロイ オール ヒューマンズ! (SLPM-66430) & (SLPM-55141)
  • The game has built in 16:9 widescreen mode. Set it in the games Options > Display > Widescreen menu.

Known Issues

Shadow like glitch

  • Status: Fixed
  • Type: Minor
  • Description: In-game a sort of "shadow" is on the screen, but blocky showing vague things of the environment. The glitch is present entire game.
  • Workaround: Switch to software mode and play it there (highly CPU demanding, but usable).

Alternatively: Use Skipdraw 5 hack. Character shadows (and some post processing effects) disappear and has texture popping issue at far away objects.

Software mode object falling

  • Status: Active
  • Type: Major
  • Description: Playing in software mode at intense fighting scenes, the game objects tend to fall through the level. (eg. grabbing vehicles with the saucer, NPCs get sometimes stuck in the ground). The player character can have this issue too, but very rarely. Probably is in connection with the demanding CPU usage.
  • Workaround: Switch back temporary to hardware mode.

Progressive mode kills menu usage

  • Status: Fixed
  • Type: Major
  • Description: Switching progressive scan on, cripples the semi transparent menu usage. It makes the game use insane amount of PC resources. eg. "60Hz warning" and "load game, new game" option at the beginning, pause menu during gameplay. Problem only exists when Skipdraw 5 is is off.
  • Workaround: Do not use progressive scan or use software mode.

(Separate Tester) Above issue not found, used Progressive Scan, and no problems at all. Also, it seems that the game gets blurrier when you use PS, so I recommend not using it at all, and if the above issue is true, doubly so. Still need to use Skipdraw 5 or Software mode though.

The gallery

Public compatibility forum links